Xintela reports positive results from preclinical ARDS study and new grant of 2.3 million SEK

#Regulatory

Lund, Sweden, 6 April 2021 - Xintela today announces the positive outcome of the  preclinical ARDS (Acute Respiratory Distress Syndrome) study partly financed by Vinnova. The results of the study  demonstrate the potential of the company's stem cell product XSTEM® in the treatment of ARDS, a life-threatening lung complication that can affect severely ill COVID-19 patients. Xintela also announces a new grant from  Swelife/Vinnova to further investigate the mechanism of action of XSTEM in the preclinical ARDS model and to prepare XSTEM for clinical studies. 

Xintela previously announced that the company's stem cell product XSTEM was being evaluated in a validated animal model of ARDS and that preliminary results showed the stem cells improve lung function and stabilise blood circulation. The study, which was partly financed by Vinnova, was carried out in collaboration with Professor Sandra Lindstedt and her team at the Department of Cardiothoracic Surgery, Skåne University Hospital in Lund.


The Vinnova-supported study has now been completed and the results confirm the therapeutic effect of XSTEM. This is based on both meassurements of clinical parameters as well as histological analyses showing less damage to lung tissue after treatment with XSTEM. The results also indicated  immunomodulatory and anti-inflammatory effect of the stem cells. 

On March 31st, Xintela received a new grant of 2.3 MSEK from Swelife/Vinnova in the call ”Samverkansprojekt för bättre hälsa – Projekt som bidrar till förbättrad prevention, diagnos, monitorering eller behandling”.  Of 129 applications, 18 were granted a total of 36 MSEK. The aim of Xintela’s project is to further investigate the mechanism of action of XSTEM in the ARDS model and prepare for clinical studies. The project is a collaboration with Skåne University Hospital and Lund University. 

-Our ARDS study has been very successful and what is extra positive is that we can see the therapeutic effects of our stem cells through both clinical parameters and histological analyses of lung tissues. We will now further evaluate these results in deciding the next steps in the development of XSTEM in ARDS. The new grant is a great support that enables us to further investigate the positive effect of XSTEM, says Xintela's CEO Evy Lundgren-Åkerlund.

Professor Sandra Lindstedt says -ARDS is a very serious condition with a high mortality rate where we currently lack good treatment options. The animal model we utilise to study ARDS is similar to the clinical situation in humans. The results we get with Xintela's stem cells in this ARDS model are therefore promising for developing an ARDS treatment.

This information is such information that Xintela AB (publ) is obligated to publish in compliance with the EU market abuse regulation. The information was provided, through the below contact, for publication at 08:55 CET on the 6th of April, 2021.

Xintela AB (publ)
Evy Lundgren-Åkerlund, CEO
Tel: +46 46 275 65 00
Email: evy@xintela.se
Medicon Village
223 81 Lund, Sweden
www.xintela.se 


About Xintela
Xintela is an Advanced Therapy company developing regenerative cell therapies and targeted cancer therapies based on the patented marker technology platform XINMARK®. The platform is built on specific cell surface proteins (integrins) and more than 25 years of research and development. Xintela uses the marker technology to isolate and quality assure stem cells for the treatment of musculoskeletal diseases including osteoarthritis (OA). Studies on horses with OA have demonstrated that the stem cells are safe and that they have a positive effect on cartilage and bone. Xintela has established an in-house GMP-facility for manufacturing of stem cells and is preparing a First in Human clinical study on patients with knee OA. In the oncology program, Xintela develops antibody-based therapies for treatment of aggressive tumors including glioblastoma and triple-negative breast cancer. Xintela is listed on Nasdaq First North Growth Market Stockholm since 22 March 2016. Xintela's Certified Adviser at Nasdaq First North Growth Market is Erik Penser Bank AB, +46 8-463 80 00, certifiedadviser@penser.se.

About Swelife

Swelife – For a competitive life science ecosystem in Sweden

Swelife is a strategic innovation programme, funded by the Swedish Government via the Swedish innovation agency, Vinnova, and by the programme’s partners. Wesupport collaboration within academia, industry and healthcare, with the goal to strengthen Life Science in Sweden and to improve public health.

www.swelife.se


Archive

Below you will find the collected information on Xintela’s press releases, newsletters, diary events, films, media coverage and analyses.

June 13, 2022
Bio International Convention, San Diego, June 13-16
Bio International Convention, San Diego, June 13-16
June 13, 2022
Småbolagsdagarna, Stockholm, June 13-15
Småbolagsdagarna, Stockholm, June 13-15
June 14, 2022

CEO Evy Lundgren-Åkerlund presents the company at Aktiespararnas Småbolagsdagarna 2022 (in Swedish).

June 14, 2022

Targinta's CEO Per Norlén presents the company at Aktiespararnas Småbolagsdagarna 2022 (in Swedish).

June 9, 2022

CEO Evy Lundgren-Åkerlund presents the company at BioStock Life Science Spring Summit 2022.

February 27, 2020

BioStock interview with Xintela's CMO and board member Sven Kili.

August 30, 2018

BioStock was given the opportunity to interview Sven Kili in connection with his visit to Sweden for board and strategy work in Xintela.

February 9, 2017

Dr. Marcus Keep comments on Xintelas glioblastoma project.

January 31, 2017

Xintelas Chairman of the board and strategic advisor Greg Batcheller, tells us more about Xintelas potential and prospects.

January 30, 2017

Dr. Lisa Fortier at Cornell University, New York is interviewed by BioStock about Xintelas positive results in horse study.

December 28, 2016

In the following video interview, Karin explains her role at Xintela and what she considers to be Xintela’s primary strengths.

December 13, 2016

See the interview with Claes Post, member of the board in Xintela. The interview is in swedish with english subtitles.

March 24, 2016

See the interview with Sven Kili, member of the board in Xintela. The interview is in English (introduction is in Swedish).

March 22, 2016

See an interview with Xintela's CEO Evy Lundgren-Åkerlund, after the listing ceremony at Nasdaq First North.

March 15, 2016

Investor presentation from Lund - Jan 27

January 14, 2016

Interview with Xintelas CEO

June 1, 2022
BioStock Studio: Xintela's CEO comments on the upcoming share issue
April 12, 2022
BioStock: Xintela's CEO on the potential in difficult-to-heal wounds
March 4, 2022
BioStock: Xintela presents plans for 2022 in its Q4 report
January 27, 2022
BioStock Studio: Targinta provides business update prior to spin-off
January 19, 2022
BioStock: Xintela advances to clinical phase in osteoarthritis and difficult-to-heal wounds 2022
October 12, 2021
BioStock: Professor Folke Sjöberg about XSTEM for treatment of venous leg ulcers.
November 9, 2020
BioStock: Xintela’s CEO comments on the positive patent notice
June 22, 2017
Xintela covered in GEN regarding its participation in multi-million, government funded initiative to form a...
March 2, 2017
Xintela covered in Horsetalk.co.nz regarding that its stem cells are safe for use in horses
March 23, 2016
(Article in Swedish) Xintela tar behandling av ledskador och cancer till First North.
March 23, 2016
(Article in Swedish) Grundare av Xintela ser notering som viktig milstolpe
March 23, 2016
(Article in Swedish) Xintela covered in Life Science Sweden
February 24, 2016
(Article in Swedish) Rapidus: Xintela på väg till First North
December 10, 2021
Edison Group has published a research update on Xintela.
July 14, 2021
Xintela, backed by its integrin biomarker technology platform XINMARK, is a potential disrupter
November 9, 2020
A status report of the Xintela has been published by Biostock
April 12, 2018
Read the full analysis here
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