Xintela reports positive results from preclinical ARDS study and new grant of 2.3 million SEK

#Regulatory

Lund, Sweden, 6 April 2021 - Xintela today announces the positive outcome of the  preclinical ARDS (Acute Respiratory Distress Syndrome) study partly financed by Vinnova. The results of the study  demonstrate the potential of the company's stem cell product XSTEM® in the treatment of ARDS, a life-threatening lung complication that can affect severely ill COVID-19 patients. Xintela also announces a new grant from  Swelife/Vinnova to further investigate the mechanism of action of XSTEM in the preclinical ARDS model and to prepare XSTEM for clinical studies. 

Xintela previously announced that the company's stem cell product XSTEM was being evaluated in a validated animal model of ARDS and that preliminary results showed the stem cells improve lung function and stabilise blood circulation. The study, which was partly financed by Vinnova, was carried out in collaboration with Professor Sandra Lindstedt and her team at the Department of Cardiothoracic Surgery, Skåne University Hospital in Lund.


The Vinnova-supported study has now been completed and the results confirm the therapeutic effect of XSTEM. This is based on both meassurements of clinical parameters as well as histological analyses showing less damage to lung tissue after treatment with XSTEM. The results also indicated  immunomodulatory and anti-inflammatory effect of the stem cells. 

On March 31st, Xintela received a new grant of 2.3 MSEK from Swelife/Vinnova in the call ”Samverkansprojekt för bättre hälsa – Projekt som bidrar till förbättrad prevention, diagnos, monitorering eller behandling”.  Of 129 applications, 18 were granted a total of 36 MSEK. The aim of Xintela’s project is to further investigate the mechanism of action of XSTEM in the ARDS model and prepare for clinical studies. The project is a collaboration with Skåne University Hospital and Lund University. 

-Our ARDS study has been very successful and what is extra positive is that we can see the therapeutic effects of our stem cells through both clinical parameters and histological analyses of lung tissues. We will now further evaluate these results in deciding the next steps in the development of XSTEM in ARDS. The new grant is a great support that enables us to further investigate the positive effect of XSTEM, says Xintela's CEO Evy Lundgren-Åkerlund.

Professor Sandra Lindstedt says -ARDS is a very serious condition with a high mortality rate where we currently lack good treatment options. The animal model we utilise to study ARDS is similar to the clinical situation in humans. The results we get with Xintela's stem cells in this ARDS model are therefore promising for developing an ARDS treatment.

This information is such information that Xintela AB (publ) is obligated to publish in compliance with the EU market abuse regulation. The information was provided, through the below contact, for publication at 08:55 CET on the 6th of April, 2021.

Xintela AB (publ)
Evy Lundgren-Åkerlund, CEO
Tel: +46 46 275 65 00
Email: evy@xintela.se
Medicon Village
223 81 Lund, Sweden
www.xintela.se 


About Xintela
Xintela is an Advanced Therapy company developing regenerative cell therapies and targeted cancer therapies based on the patented marker technology platform XINMARK®. The platform is built on specific cell surface proteins (integrins) and more than 25 years of research and development. Xintela uses the marker technology to isolate and quality assure stem cells for the treatment of musculoskeletal diseases including osteoarthritis (OA). Studies on horses with OA have demonstrated that the stem cells are safe and that they have a positive effect on cartilage and bone. Xintela has established an in-house GMP-facility for manufacturing of stem cells and is preparing a First in Human clinical study on patients with knee OA. In the oncology program, Xintela develops antibody-based therapies for treatment of aggressive tumors including glioblastoma and triple-negative breast cancer. Xintela is listed on Nasdaq First North Growth Market Stockholm since 22 March 2016. Xintela's Certified Adviser at Nasdaq First North Growth Market is Erik Penser Bank AB, +46 8-463 80 00, certifiedadviser@penser.se.

About Swelife

Swelife – For a competitive life science ecosystem in Sweden

Swelife is a strategic innovation programme, funded by the Swedish Government via the Swedish innovation agency, Vinnova, and by the programme’s partners. Wesupport collaboration within academia, industry and healthcare, with the goal to strengthen Life Science in Sweden and to improve public health.

www.swelife.se


Archive

Below you will find the collected information on Xintela’s press releases, newsletters, diary events, films, media coverage and analyses.

April 12, 2021
Xintela GMP inspection for manufacturing license completed
April 6, 2021
Xintela reports positive results from preclinical ARDS study and new grant of 2.3 million SEK
March 19, 2021
Xintela gets tissue establishment license
March 17, 2021
Xintela gets patent grant in Europe for XSTEM stem cell product
March 12, 2021
Xintela publishes results from glioblastoma antibody study
February 26, 2021
Year-end report 1 Jan 2020 – 31 Dec 2020
January 7, 2021
Xintela receives Notice of Allowance from USPTO for the treatment of brain tumors
December 21, 2020
Xintela submits manufacturing license application
December 14, 2020
Xintela recruits Jeffrey Abbey to Targinta
December 4, 2020
Arbitral award rendered in favour of Xintela in dispute with former underwriters
December 3, 2020
Xintela Board recommends Maarten de Château as new Board member
November 27, 2020
Xintela publishes interim report for the third quarter of 2020
November 12, 2020
Xintela Board recommends Lars Hedbys as new Board member
October 30, 2020
Status report of Xintela published by BioStock
October 29, 2020
Xintela receives ‘intention to grant’ decision from European Patent Office for stem cell product XSTEM
October 28, 2020
Xintela applies for tissue establishment license
October 26, 2020
Xintela's stem cells show promising results in preclinical ARDS study
August 19, 2020
Xintela strengthens management team
July 29, 2020
Xintela receives Notice of Allowance from USPTO
June 23, 2020
Granted preliminary approval from the European Patent Office for the treatment of brain tumors
June 17, 2020
Xintela develops treatment for aggressive breast cancer
May 8, 2020
Xintela granted 1 million SEK from Vinnova
March 27, 2020
Xintela has been granted 2 million SEK from Vinnova in the call for "Innovation projects in small and medium-sized companies"
February 3, 2020
Positive preclinical results from equine study
December 11, 2019
Positive preclinical results in Xintela’s glioblastoma project
November 29, 2019
Interim report 1 JAN 2019-30 SEP 2019
April 26, 2019
The Board of Xintela AB (publ) announces that Peter Edman has been nominated for election to the Board at the annual general meeting
April 26, 2019
The results of the company's glioblastoma study have now been published in the renowned international scientific journal Cancers.
April 16, 2019
Xintela appoints Sven Kili as Chief Operating Officer
February 27, 2019
Xintela publishes its Year-end Report for 2018
February 15, 2019
Xintela publishes results from stem cell study
January 8, 2019
Xintela broadens and extends patent protection for chondrocyte products and chondrocyte markers
October 25, 2018
The parties intend to jointly develop an ADC therapeutic product with a first focus on glioblastoma
August 29, 2018
Xintela has made the decision to spin out its oncology business to a newly formed subsidiary company, Targinta AB.
August 29, 2018
Sven Kili extends his commitment to Xintela as Chief Medical Officer
August 21, 2018
Xintela announces an update on the company's development programs
August 9, 2018
Xintela today announced that the company's international patent application has been published
July 9, 2018
Xintela signs Letter of Intent with CO.DON
June 28, 2018
Xintela receives MUMS-status for the treatment of osteoarthritis in horses
April 26, 2018
Xintela's GMP facility is completed and being prepared for production and clinical trials
April 17, 2018
Xintela develops unique methods in stem cell therapy for the brain and broadens patent portfolio
March 20, 2018
Xintela prepares for a possible spin-out of its oncology business into a separate company
February 22, 2018
Xintela publishes the Year-end Report for 2017-01-01 - 2017-12-31
December 29, 2017
Xintela licenses human antibody technology for cancer therapy
December 19, 2017
Xintela to collaborate with Japanese CellSeed Inc.
November 13, 2017
Xintela raises 17 million SEK in debt and equity
October 17, 2017
Keld Søndergaard has resigned from the company’s Board of Directors, citing personal reasons.
September 11, 2017
Xintela building own GMP-facility for stem cell production
July 17, 2017
Xintela recruits Liselotte Theorell as Director Product Development and Quality Management
June 22, 2017
Xintela participates in multi-million, government funded initiative to form a cell and gene therapy research center
May 22, 2017
Xintela signs Memorandum of Understanding with the leading European cell therapy company, CO.DON
May 9, 2017
Xintela: Keld Sondergaard nominated as new board member
March 21, 2017
Xintela announces today that Thomas Areschoug has been recruited to the business development team......
February 8, 2017
(In Swedish) Xintela: Insynspersoner och huvudägare avser nyttja teckningsoptioner av serie TO1
January 20, 2017
Xintela reports positive preclinical results in cancer project
January 4, 2017
Xintela´s stem cells show positive treatment effects on cartilage damage in horse study
December 22, 2016
Xintela reports positive results from completed horse study
September 12, 2016
Xintela announces that Rickard Mosell has been recruited as Head of Business Development from October 1, 2016.
August 22, 2016
Xintela today announces that it has settled a dispute and will receive 1,500,000 Swedish Crowns in compensation.
June 23, 2016
Xintela announces that Christer Betsholtz has been engaged as a scientific and strategic advisor
June 1, 2016
Xintela strengthens its organisation wih the appointment of Caroline Ehrencrona as Director Clincial Development and Regulatory Affairs
April 25, 2016
Xintela initiates a study on the treatment of cartilage damage in horses in the USA.
March 16, 2016
Xintela's press releases are currently only published in Swedish. Please contact us if you have further questions.
January 26, 2021
Xintela Newsletter December 2020
November 9, 2020
Xintela is targeting several important milestones in the remainder of 2020 and 2021
January 13, 2020
Newsletter December 2019
July 30, 2019
Newsletter July 2019
May 8, 2019
Projects in both regenerative medicine and oncology are making progress and developing very positively.
January 14, 2019
Xintela has worked intensively to connect the company with potential partners and international investors.
January 14, 2019
The following presentation summarises the status of Xintela’s various activities and overall plans for the coming year.
July 17, 2018
Strong first six months for Xintela
March 27, 2018
Large-scale stem cell production paves the way for GMP-certified production
January 5, 2018
Pre-Christmas breakthrough promises an exciting 2018
September 28, 2017
‍Strategic decisions that builds significant value
July 19, 2017
Focusing on Stem Cell Production and Preparations for Clinical Trials
May 16, 2017
On the 21st March 2017, Xintela reported that it was strengthening its Business Development team...
April 5, 2017
A word from the CEO
February 15, 2017
The subscription period for shares supported by warrants has started
December 29, 2016
A Year of Significant Progress
December 14, 2016
Glioblastoma—Xintela's Focus in the Cancer Arena
November 8, 2016
Starting the Autumn with an increased focus on Xintela’s commercial development
October 19, 2016
Since our listing in the Spring, the company has developed in a very positive way and we are on track with the milestones we have set.
August 11, 2016
Confidence in the future with a strong organisation
August 11, 2016
Welcome to Xintela's newsletter
June 10, 2021
10-11 & 14-18 June: BIO Digital
BIO Digital 10-11 & 14-18 June
May 17, 2021
17-20 May: Biotechgate Digital Partnering
Biotechgate Digital Partnering 17-20 May
April 6, 2021
6-9 April: Cell&Gene on the Med
Cell&Gene on the Med 6-9 April
March 25, 2021
23-25 March: Bio Europe Spring Digital
Bio Europe Spring Digital 23-25 March
March 2, 2021
2-5 March: Oncology Virtual Partnering
Oncology Virtual Partnering 2-5 March
February 27, 2020

BioStock interview with Xintela's CMO and board member Sven Kili.

August 30, 2018

BioStock was given the opportunity to interview Sven Kili in connection with his visit to Sweden for board and strategy work in Xintela.

February 9, 2017

Dr. Marcus Keep comments on Xintelas glioblastoma project.

January 31, 2017

Xintelas Chairman of the board and strategic advisor Greg Batcheller, tells us more about Xintelas potential and prospects.

January 30, 2017

Dr. Lisa Fortier at Cornell University, New York is interviewed by BioStock about Xintelas positive results in horse study.

December 28, 2016

In the following video interview, Karin explains her role at Xintela and what she considers to be Xintela’s primary strengths.

December 13, 2016

See the interview with Claes Post, member of the board in Xintela. The interview is in swedish with english subtitles.

March 24, 2016

See the interview with Sven Kili, member of the board in Xintela. The interview is in English (introduction is in Swedish).

March 22, 2016

See an interview with Xintela's CEO Evy Lundgren-Åkerlund, after the listing ceremony at Nasdaq First North.

March 15, 2016

Investor presentation from Lund - Jan 27

January 14, 2016

Interview with Xintelas CEO

November 9, 2020
BioStock: Xintela’s CEO comments on the positive patent notice
June 22, 2017
Xintela covered in GEN regarding its participation in multi-million, government funded initiative to form a...
March 2, 2017
Xintela covered in Horsetalk.co.nz regarding that its stem cells are safe for use in horses
March 23, 2016
(Article in Swedish) Xintela tar behandling av ledskador och cancer till First North.
March 23, 2016
(Article in Swedish) Grundare av Xintela ser notering som viktig milstolpe
March 23, 2016
(Article in Swedish) Xintela covered in Life Science Sweden
February 24, 2016
(Article in Swedish) Rapidus: Xintela på väg till First North
November 9, 2020
A status report of the Xintela has been published by Biostock
April 12, 2018
Read the full analysis here
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